The following references are from independent and highly respected institutions investigating the benefits of negative ions. These references are merely a small sample of the extensive testing that has been undertaken over decades of research.

Importantly, these references are not ‘marketing hype’, nor is it ‘in-house’ or ‘paid research’ on behalf of Vital-ion, but genuine research detailing the health benefits of negative ions.

Ryushi, T, Kita, I, Sakurai, T, Yasumatsu, M, Isokawa, M, Aihara, Y & Hama, K.
The effect of exposure to negative air ions on the recovery of physiological responses after moderate endurance exercise,. International Journal of Biometeorology. 1998 Feb; 41(3)132-6.
Quote: “The diastolic blood pressure (DBP) values during the recovery period were significantly lower in the presence of negative ions than in their absence. The plasma levels of serotonin (5-HT) and dopamine (DA) were significantly lower in the presence of negative ions than in their absence.”

Nakane H, Asami O, Yamada Y, Ohira H.
Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity. International Journal of Psycholphysiology. 2002 Oct; 46(1):85-9.
Quote: “Task performance was not slightly but significantly improved by the presence of negative air ions. These results suggest that negative air ions are effective for the reduction of and the prompt recovery from stress caused by computer operation.”

Goel N, Terman M, Terman J.S, Macchi M.M, & Steward, J.W.
Comtrolled trial of bright light and negative air ions for chronic depression.
Psychological Medicine. 2005 Jul;35(7):945-55
Quote: “Both bright light and negative air ions are effective for treatment of chronic depression.”

Baron, R.
Effects of negative ions on cognitive performance.
Journal of Applied Psychology. 1987 Feb Vol 72(1) 131-137
Quote: “Together, the findings of these studies suggest that negative air ions can indeed exert appreciable effects on cognitive performance.”

Howard, P.J Ph.D.
Negative Ions for the Brain.
The Owner’s Manual for the Brain: Everyday Applications from Mind-Brain Reserarch. Second Edition. 2000. Bard Press, Texas, USA
Quote: “High concentrations of negative ions are essential for high energy and positive mood”. “If you deplete the air of negative ions, you experience an increase in serotonin and its attendant drowsiness and relaxation – not what you want when mental agility is demanded.